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Drosophila Keap1 Proteins Assemble Nuclear Condensates in Response to Oxidative Stress

The Keap1-Nrf2 signaling pathway is a central regulator of transcriptional responses to oxidative stress and is strongly linked to diverse pathologies, particularly cancer. In the cytoplasm, Keap1 (Kelch-like ECH-associated protein 1) promotes proteasomal degradation of Nrf2 (NF-E2–related factor 2)...

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Autori principali: Guangye Ji, Bethany Cross, Thomas Killmer, Bee Enders, Emma Neidviecky, Hayden Huber, Grace Lynch, Huai Deng
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-01-01
Serie:Antioxidants
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Accesso online:https://www.mdpi.com/2076-3921/15/1/134
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