Piezo1 protects against inflammatory bone loss via a unique Ca2+-independent mechanism in osteoclasts

IntroductionBone integrity relies on mechanical stimulation, and its absence, such as in disuse osteoporosis or periodontitis, enhances osteoclast-mediated resorption. Although Piezo1 is a well-characterized mechanosensitive ion channel in several cell types, its function in osteoclast lineage cells...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Satoru Shindo, Shin Nakamura, Avery Hawthorne, Alireza Heidari, Maria Rita Pastore, Motoki Okamoto, Maiko Suzuki, Manuel Salinas, Takumi Memida, Dmitriy Minond, Alexander Bontempo, Mark Cayabyab, Yingzi Yang, Janet L Crane, Maria Hernandez, Saynur Vardar, Patrick Hardigan, Xiaozhe Han, Steven Kaltman, Toshihisa Kawai
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2025-09-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	Piezo1 periodontitis osteoclast mechanosensing PP2A Akt
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1661538/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!