Impact of TSPO Receptor Polymorphism on [¹⁸F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders

TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [¹⁸F]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [¹⁸F]GE-180...

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Автори:	Franziska J. Vettermann, Stefanie Harris, Julia Schmitt, Marcus Unterrainer, Simon Lindner, Boris-Stephan Rauchmann, Carla Palleis, Endy Weidinger, Leonie Beyer, Florian Eckenweber, Sebastian Schuster, Gloria Biechele, Christian Ferschmann, Vladimir M. Milenkovic, Christian H. Wetzel, Rainer Rupprecht, Daniel Janowitz, Katharina Buerger, Robert Perneczky, Günter U. Höglinger, Johannes Levin, Christian Haass, Joerg C. Tonn, Maximilian Niyazi, Peter Bartenstein, Nathalie L. Albert, Matthias Brendel
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2021-05-01
Серія:	Life
Предмети:	microglia neurodegeneration Alzheimer’s disease neuro-oncology 4R-tauopathy TSPO-PET
Онлайн доступ:	https://www.mdpi.com/2075-1729/11/6/484
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