ZEB1 and ALKBH5 coregulate CRABP2 and FABP5 and jointly determine the sensitivity of anaplastic thyroid cancers to gemcitabine and retinoic acid

Abstract Retinoic acid (RA) signaling through CRABP2 and FABP5 differentially influences therapeutic responses and drug resistance in anaplastic thyroid cancer (ATC), yet regulatory mechanisms remain unclear. Our study reveals low CRABP2 and high FABP5 expression in ATC cell lines (THJ-11T/16T/21T),...

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Autores principales:	Xiaoting Tian, Kunlun Peng, Tianlei Zhao, Bin Jia, Qinghe Ma, Yayou Miao, Suyang Yang, Jiao Wu, Lifang Ma, Dongwei Su, Xiao Zhang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-10-01
Colección:	npj Precision Oncology
Acceso en línea:	https://doi.org/10.1038/s41698-025-01073-7
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