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Osteopontin-4 (OPN-4) Suppresses Tumor Progression Features Whilst Sensitizing c643 Anaplastic Thyroid Cells to Sorafenib

<b>Background/Objectives</b>: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal forms of malignant neoplasm of the endocrine system, and osteopontin (OPN) has been shown to be aberrantly expressed in this tumor type. Among the five OPN splicing isoforms (OPN-SI), OPN-4 has...

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Principais autores: Gabriela Ribeiro Silva, Amanda Lewis Rubim, Flavia da Cunha Vasconcelos, Luciana Bueno Ferreira, John Greenman, Etel Rodrigues Pereira Gimba
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2026-04-01
Series:Biomedicines
Assuntos:
osteopontin
splicing isoforms
splicing
OPN-4
spheroids
anaplastic thyroid carcinoma
Acceso en liña:https://www.mdpi.com/2227-9059/14/5/989
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