Collagen-mediated pro-tumorigenic MAPK activation drives stromal-immune reprogramming in solid cancers

IntroductionIntratumoral collagen deposition is a hallmark of solid cancers and plays a critical role in shaping the tumor microenvironment (TME). This study aimed to characterize the clinical and molecular implications of collagen deposition and elucidate its role in modulating TME components and s...

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Autori principali:	Junli Ding, Hongxin Lin, Hanfang Fan, Liangfeng Xu, Haihua Zhou, Huning Jiang, Zeyu Wang, Tiansong Xia, Yun Cai, Yichao Zhu, Junying Xu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-02-01
Serie:	Frontiers in Immunology
Soggetti:	collagen deposition M2 macrophage MAPK microvessel density pan-cancer
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1744126/full
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