Establishment and Characterization of a Stable Producer Cell Line Generation Platform for the Manufacturing of Clinical-Grade Lentiviral Vectors

<b>Background/Objectives:</b> To date, nearly 300 lentiviral-based gene therapy clinical trials have been conducted, with eight therapies receiving regulatory approval for commercialization. These advances, along with the increased number of advanced-phase clinical trials, have prompted contract dev...

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Hauptverfasser:	Ane Arrasate, Igone Bravo, Carlos Lopez-Robles, Ane Arbelaiz-Sarasola, Maddi Ugalde, Martha Lucia Meijueiro, Miren Zuazo, Ana Valero, Soledad Banos-Mateos, Juan Carlos Ramirez, Carmen Albo, Andrés Lamsfus-Calle, Marie J. Fertin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-10-01
Schriftenreihe:	Biomedicines
Schlagworte:	lentiviral vectors gene therapy stable producer cell line lentiviral packaging cell line cell line development
Online-Zugang:	https://www.mdpi.com/2227-9059/12/10/2265
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