Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents

BackgroundRecent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging. p16 and p21 are classical molecules involved in mediating cellular senescence. In our previous st...

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Autors principals:	Xiaohui Lu, Yongli Han, Jiaming Song, Qin Wan, Pengfei Liu, Li Chen, Yufeng Wang, Pingping Xue, Xiuliang Dai
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-07-01
Col·lecció:	Frontiers in Endocrinology
Matèries:	p21 cellular senescence premature ovarian insufficiency alkylating agents defective folliculogenesis primordial follicle activation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1616965/full
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