In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

IntroductionThe first-in-class diarylquinoline (DARQ) bedaquiline (BDQ) is in the medicines list for drug-resistant tuberculosis. TBAJ-587 is a next-generation DARQ with improved anti-Mycobacterium tuberculosis (Mtb) activity and reduced cardiac repolarization abnormalities.MethodsThe in vitro effic...

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Egile Nagusiak:	Diana Angelica Aguilar-Ayala, Marie Sylvianne Rabodoarivelo, Maxime R. Eveque-Mourroux, Albin A. M. Leding, Lindsay Sonnenkalb, Ana Picó Marco, Nicolas Willand, Natalya Serbina, Ulrika S. H. Simonsson, Ainhoa Lucía, Santiago Ramón-García
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2026-06-01
Saila:	Frontiers in Microbiology
Gaiak:	diarylquinoline pharmacokinetics/pharmacodynamics TBAJ-587 time-kill assay tuberculosis
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1828998/full
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