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Rapid Development of an Effective Newcastle Disease Virus Vaccine Candidate by Attenuation of a Genotype VII Velogenic Isolate Using a Simple Infectious Cloning System

Genotype-matched vaccines provide ideal protection against infection caused by new Newcastle disease virus (NDV) genotypes or variants even in the vaccinated chickens. In this study, we report a protocol for attenuation and rapid development of a velogenic NDV isolate as an effective vaccine candida...

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Principais autores: Nannan Wang, Mei Huang, To Sing Fung, Qiong Luo, Jun Xian Ye, Qian Ru Du, Liang Hai Wen, Ding Xiang Liu, Rui Ai Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-09-01
coleção:Frontiers in Veterinary Science
Assuntos:
newcastle disease
reverse genetics
attenuated strains
immune protection
vaccination
Acesso em linha:https://www.frontiersin.org/article/10.3389/fvets.2020.00648/full
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