α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease

Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors encoding wild-type human α-synuclein produced a rat...

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Principais autores:	Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-12-01
Series:	Biomedicines
Assuntos:	adeno-associated viral vectors α-synuclein autoradiography dopamine neuroinflammation synaptic vesicle glycoprotein 2A
Acceso en liña:	https://www.mdpi.com/2227-9059/9/12/1876
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