Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration

Autophagy is characterized as a cytoprotective process and inhibition of autophagy with medicinally active agents, such as chloroquine (CQ) is proposed as a prospective adjuvant therapy for cancer. Here, we examined the preclinical effects of CQ combined with the MEK inhibitor trametinib (TRA) on me...

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Hlavní autoři:	Simone Degan, Brian L. May, Yingai J. Jin, Manel Ben Hammouda, Huiying Sun, Guoqiang Zhang, Yan Wang, Detlev Erdmann, Warren Warren, Jennifer Y. Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-06-01
Edice:	Frontiers in Oncology
Témata:	melanoma autophagy chloroquine MEK tremetinib immune cell infiltration
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2022.782877/full
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