Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications
Neprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous system. NEP’s involvement in metabolizing natriuretic peptides, insulin, and enkephalins makes it a promising target for tr...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2024-12-01
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| Schriftenreihe: | Frontiers in Pharmacology |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1501407/full |
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