Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study

Abstract Sepsis, a syndrome of life-threatening organ dysfunction caused by dysregulated host responses to infection, exhibits profound pathobiological heterogeneity, hindering the development of effective therapies. Current subtyping approaches, often reliant on single-omics data or unsupervised cl...

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Dettagli Bibliografici

Autori principali:	Zhongheng Zhang, Lin Chen, Hongjie Shen, Jing Wang, Jie Yang, Suibi Yang, Weimin Zhang, Xuandong Jiang, Xiaojun Wu, Xianglin Meng, Fengzhi Zhao, Wanjie Gu, Haiyan Yin, Lihui Wang, Yuetian Yu, Lingxia Cheng, Ping Xu, Danting Fei, Huijie Yu, Xuning Shen, Yuhong Jin, Bingyang Liu, Jian Sun, Hongying Ni, Mihir R. Atreya, Paul W. G. Elbers, Kwok Ming Ho, Leo Anthony Celi, Chinese Multi-omics Advances In Sepsis (CMAISE) Consortium
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-11-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-025-65271-4
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