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Integration of Proteomics and Metabolomics Into the Design, Build, Test, Learn Cycle to Improve 3-Hydroxypropionic Acid Production in Aspergillus pseudoterreus

Biological engineering of microorganisms to produce value-added chemicals is a promising route to sustainable manufacturing. However, overproduction of metabolic intermediates at high titer, rate, and yield from inexpensive substrates is challenging in non-model systems where limited information is...

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Principais autores: Kyle R. Pomraning, Ziyu Dai, Nathalie Munoz, Young-Mo Kim, Yuqian Gao, Shuang Deng, Joonhoon Kim, Beth A. Hofstad, Marie S. Swita, Teresa Lemmon, James R. Collett, Ellen A. Panisko, Bobbie-Jo M. Webb-Robertson, Jeremy D. Zucker, Carrie D. Nicora, Henrique De Paoli, Scott E. Baker, Kristin E. Burnum-Johnson, Nathan J. Hillson, Jon K. Magnuson
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-04-01
Serier:Frontiers in Bioengineering and Biotechnology
Fag:
3-hydroxypropionic acid (3-HP)
Aspergillus pseudoterreus
beta-alanine pathway
Agile BioFoundry
3HP
Online adgang:https://www.frontiersin.org/articles/10.3389/fbioe.2021.603832/full
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