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Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Abstract Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediat...

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Hauptverfasser: Manuela Sánchez-Feutrie, Montserrat Romero, Sónia R. Veiga, Núria Borràs-Ferré, Nick Berrow, Martina Ràfols, Noemí Giménez, Andrea Rodgers-Furones, Alba Sabaté-Pérez, Ángela Rodríguez Pérez, Luis Rodrigo Cataldo, Hans Burghardt, David Sebastián, Natàlia Plana, Vanessa Hernández, Laura Isabel Alcaide, Óscar Reina, Maria J. Monte, José Juan G. Marin, Manuel Palacín, Remy Burcelin, Per Antonson, Jan-Ake Gustafsson, Antonio Zorzano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-09-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-025-62255-2
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