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Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation

Genome wide association meta-analysis identified ST3GAL3, a gene encoding the beta-galactosidase-alpha-2,3-sialyltransferase-III, as a risk gene for attention-deficit/hyperactivity disorder (ADHD). Although loss-of-function mutations in ST3GAL3 are implicated in non-syndromic autosomal recessive int...

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Principais autores: Olga Rivero, Judit Alhama-Riba, Hsing-Ping Ku, Matthias Fischer, Gabriela Ortega, Péter Álmos, David Diouf, Daniel van den Hove, Klaus-Peter Lesch
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-09-01
coleção:Frontiers in Genetics
Assuntos:
St3gal3
sialyltransferase
sialic acid
psychiatric disorders
attention-deficit/hyperactivity disorder (ADHD)
prefrontal cortex
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2021.688488/full
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