MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays

Abstract Ribosomes scanning from the mRNA 5′ cap to the start codon may initiate at upstream open reading frames (uORFs), decreasing protein biosynthesis. Termination at a uORF can lead to re-initiation, where 40S subunits resume scanning and initiate another translation event downstream. The noncan...

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Hauptverfasser:	Romane Meurs, Mara De Matos, Adrian Bothe, Nicolas Guex, Tobias Weber, Aurelio A Teleman, Nenad Ban, David Gatfield
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2025-01-01
Schriftenreihe:	The EMBO Journal
Schlagworte:	uORF Re-Initiation DENR-MCTS1 eIF2D In Vitro Translation
Online-Zugang:	https://doi.org/10.1038/s44318-024-00347-3
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