Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats

Abstract Leak K+ currents are mediated by two-pore domain K+ (K2P) channels and are involved in controlling neuronal excitability. Of 15 members of K2P channels cloned so far, TRAAK, TREK-1, and TREK-2 are temperature sensitive. In the present study, we show that strong immunoreactivity of TRAAK, TR...

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Bibliografische gegevens

Hoofdauteurs:	Viacheslav Viatchenko-Karpinski, Jennifer Ling, Jianguo G. Gu
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2018-07-01
Reeks:	Molecular Brain
Onderwerpen:	Dorsal root ganglion neurons Leak K+ currents Two-pore domain K+ channels Temperature sensitivity Pain Cold allodynia
Online toegang:	http://link.springer.com/article/10.1186/s13041-018-0384-5
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