Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model

IntroductionHypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways. Therefore, we investigated whether the combination...

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Principais autores:	Sylvia J. Wowro, Giang Tong, Jana Krech, Nele Rolfs, Felix Berger, Katharina R. L. Schmitt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-06-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	cyclosporin A hypothermia oxygen-glucose deprivation/reperfusion organotypic hippocampal slice culture BV-2 microglia primary neuron
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fncel.2019.00273/full
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