Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)

Diphthamide is a highly conserved modification of archaeal and eukaryal translation elongation factor 2 (EF2) and yet why cells need EF2 to contain diphthamide is unclear. In yeast, the first steps of diphthamide synthesis and the genes (DPH1-DPH5) required to form the intermediate diphthine are wel...

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Autores principales:	Raffael Schaffrath, Michael J. R. Stark
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Shared Science Publishers OG 2014-05-01
Colección:	Microbial Cell
Materias:	EF2 modification diphthamide DPH1-DPH7 diphtheria toxin sordarin fungicides budding yeast Saccharomyces cerevisiae
Acceso en línea:	http://microbialcell.com/researcharticles/decoding-the-biosynthesis-and-function-of-diphthamide-an-enigmatic-modification-of-translation-elongation-factor-2-ef2/
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