Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial

Abstract Background Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effus...

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Detalhes bibliográficos

Principais autores:	Zhaohua Zhu, Qinghong Yu, Xiaomei Leng, Weiyu Han, Zhanguo Li, Cibo Huang, Jieruo Gu, Yi Zhao, Kang Wang, Tianwang Li, Yifang Mei, Jianhua Xu, Zhiyi Zhang, David Hunter, Flavia Cicuttini, Xiaofeng Zeng, Changhai Ding
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-09-01
Colecção:	Trials
Assuntos:	Methotrexate Osteoarthritis Effusion-synovitis Pain
Acesso em linha:	http://link.springer.com/article/10.1186/s13063-020-04687-3
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