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Modulation of glucocorticoid receptor function under iron overload

Acute iron overload leads to ferroptosis, in a mouse model of FeSO4 challenge causing lethal shock, associated with inflammation and multiple organ failure (MOF). We investigated molecular aspects causing this phenomenon upon FeSO4 overload, with a focus on the glucocorticoid receptor (GR), an impor...

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Huvudupphov: Wanting Zhu, Tineke Vanderhaeghen, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Nicolette J. D. Verhoog, Claude Libert
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2025-06-01
Serie:Frontiers in Immunology
Ämnen:
iron
glucocorticoids
ferroptosis
function
critical illnesses
Länkar:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605420/full
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