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MMR deficiency is frequent in colorectal carcinomas with diffuse SLFN11 immunostaining: clinicopathologic and molecular study of 31 cases identified among 3,300 tumors

Abstract Schlafen 11 (SLFN11), a regulator of cell fate following DNA injury, sensitizes tumor cells to DNA‐damaging agents. Patients with SLFN11‐positive tumors may benefit from DNA‐damaging chemotherapies. SLFN11 has been studied in different types of cancer including colorectal carcinomas. Howeve...

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Principais autores: Maciej Kaczorowski, Małgorzata Chłopek, Ondřej Daum, Kris Ylaya, Tomáš Vaněček, Magdalena Szczepaniak, Karol Krawczyk, Artur Kowalik, Michal Michal, Jerzy Lasota, Markku Miettinen
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-03-01
coleção:The Journal of Pathology: Clinical Research
Assuntos:
SLFN11
colorectal cancer
mismatch repair proteins
Lynch syndrome
mucinous carcinoma
DNA damaging agents
Acesso em linha:https://doi.org/10.1002/2056-4538.70025
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