Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural analyses

IntroductionImmune checkpoint inhibitor-induced isolated adrenocorticotropic hormone (ACTH) deficiency (ICI-IAD) represents a critical endocrine immune-related adverse event (irAE) that may become life-threatening without timely diagnosis. Most cases present with suppressed ACTH and cortisol levels;...

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Bibliografiske detaljer

Principais autores:	Yuria Ishibashi, Ryuta Baba, Akira Okada, Yu Otagaki, Takaya Kodama, Gentaro Egusa, Gaku Nagano, Tsuguka Matsuda, Ryoichi Miura, Atsushi Ono, Masataka Tsuge, Noboru Hattori, Haruya Ohno
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2025-10-01
Serier:	Frontiers in Endocrinology
Fag:	immune checkpoint inhibitor (ICI) adrenocorticotropic hormone (ACTH) hypophysitis immune-related adverse events (irAEs) adrenal insufficiency isolated adrenocorticotropic hormone deficiency
Online adgang:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1683546/full
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