The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response[S]

Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress. Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown that markers of ER stress/UPR activat...

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Detalhes bibliográficos

Principais autores:	Sana Basseri, Šárka Lhoták, Arya M. Sharma, Richard C. Austin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2009-12-01
coleção:	Journal of Lipid Research
Assuntos:	ER stress obesity adipocyte differentiation 3T3-L1
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520306714
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