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Molecular Basis of BRAF Inhibitor Resistance in Melanoma: A Systematic Review

<b>Background</b>: Melanoma, the deadliest human skin cancer, frequently harbors activating BRAF mutations, with V600E being the most prevalent. These alterations drive constitutive activation of the MAPK pathway, promoting uncontrolled cell proliferation, survival, and dissemination. The advent of...

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Main Authors: Ilaria Cosci, Valentina Salizzato, Paolo Del Fiore, Jacopo Pigozzo, Valentina Guarneri, Simone Mocellin, Alberto Ferlin, Sara Mathlouthi, Luisa Piccin, Mariangela Garofalo
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-08-01
Series:Pharmaceuticals
Subjects:
melanoma
BRAF mutation
V600E
MAPK pathway
targeted therapy
BRAF inhibitors (BRAFi)
Online Access:https://www.mdpi.com/1424-8247/18/8/1235
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