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Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones

Abstract Background Primary hyperoxaluria type 1 (PH1) is associated with nephrocalcinosis (NC) and calcium oxalate (CaOx) kidney stones (KS). Populations of urinary extracellular vesicles (EVs) can reflect kidney pathology. The aim of this study was to determine whether urinary EVs carrying specifi...

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Principais autores: Muthuvel Jayachandran, Stanislav V. Yuzhakov, Sanjay Kumar, Nicholas B. Larson, Felicity T. Enders, Dawn S. Milliner, Andrew D. Rule, John C. Lieske
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-11-01
coleção:Orphanet Journal of Rare Diseases
Assuntos:
Microvesicles
Exosomes
Urinary vesicles
Urinary proteins
Oxalate
Renal calcification
Acesso em linha:http://link.springer.com/article/10.1186/s13023-020-01607-1
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