P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell‐Derived Cardiomyocytes in 3‐Dimensional Suspension Culture Via FOXO‐FOXM1 Regulation

Background Current protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when hiPSC‐CMs are injected into large animal models. Thus, understa...

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Detalhes bibliográficos

Principais autores:	Nivedhitha Velayutham, Jessica C. Garbern, Hannah L. T. Elwell, Zhu Zhuo, Laura Rüland, Farid Elcure Alvarez, Sara Frontini, Yago Rodriguez Carreras, Marie Eichholtz, Elisabeth Ricci‐Blair, Jeanna Y. Shaw, Aldric H. Bouffard, Morgan Sokol, Estela Mancheño Juncosa, Seth Rhoades, Daphne van den Berg, Alexander Kreymerman, Junya Aoyama, Jens Höfflin, Herb Ryan, Shannan Ho Sui, Richard T. Lee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-07-01
Colecção:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	cardiomyocytes FOXM1 FOXO maturation p53 stem cells
Acesso em linha:	https://www.ahajournals.org/doi/10.1161/JAHA.123.033155
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