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Spongiform pathology in mouse CNS lacking ‘neuropathy target esterase’ and cellular prion protein

Conditional inactivation of the ‘neuropathy target esterase’ (NTE) gene in mouse nerve cells was previously shown to result in CNS pathology comparable to the spongiform encephalopathy characteristic of prion diseases. To determine whether cellular prion protein (PrPc) is essential for development o...

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Autors principals: Jack Rosenbluth, Rolf Schiff, Pokman Lam, Tal Nuriel, Moses V. Chao
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2009-09-01
Col·lecció:Neurobiology of Disease
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S0969996109001417
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