Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer deaths in North America with ~12% survival 5 years after diagnosis. Risk factors for PDAC, including smoking and chronic pancreatitis, trigger the unfolded protein response (UPR). Global deletion of Activating Transc...

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Hlavní autoři:	Mickenzie B. Martin, Fatemeh Mousavi, Gavin Goebel, Domenic Di Stasi, Alesia Mano, Andrei Glogov, Liena Zhao, Gianni Di Guglielmo, Parisa Shooshtari, Christopher L. Pin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2025-11-01
Edice:	Cell Death Discovery
On-line přístup:	https://doi.org/10.1038/s41420-025-02777-2
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