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Remimazolam attenuated lipopolysaccharide-induced behavioral deficits and neuronal injury via activation of the Nrf2 pathway

Abstract Sepsis is a severe disorder that is always accompanied by brain injury and dysfunction. This study aimed to evaluate the effects of remimazolam, a new ultra-short-acting sedative, on LPS-induced neuronal injury, and the role of Nrf2 signaling pathway involved. LPS was administered to Spragu...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yi Wei, Sining Pan, Zhan Zhou, Ying Yang, Tianxiao Liu, Jing Chen, Yubo Xie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-04-01
Schriftenreihe:Scientific Reports
Schlagworte:
Remimazolam
LPS
Neurotoxicity
Oxidative stress
Nrf2
Online-Zugang:https://doi.org/10.1038/s41598-025-95379-y
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