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Machine learning-driven proteomics classifier deciphers tumor origins of primary and metastatic squamous cell carcinomas

Abstract Squamous cell carcinoma (SCC) occurs across multiple organs with highly similar histology, making the diagnosis of SCC of unknown primary (SCCUP) particularly challenging. To address this, we established a machine learning–based 39-protein biomarker classifier (39PBC) trained on proteomic p...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tianqi Gong, I. Weng Lao, Chan Fong Chio, Xiaowei Zhang, Min Ren, Weiwei Li, Ning Qu, Xiaotian Ni, Tongqing Gong, Yanzi Gu, Guangqi Qin, Xiaoqun Yang, Yu Deng, Yan Xu, Zebing Liu, Kun Tao, Yingyong Hou, Sio In Wong, Qifeng Wang, Wenfeng Wang, Jian Wang, Yuan Li, Wenxing Qin, Zhiguo Luo, Xiaoyan Zhou, Jun Qin, Midie Xu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-01-01
Schriftenreihe:Biomarker Research
Schlagworte:
Squamous cell carcinoma
Tumor origin
Machine learning
Proteomics
Classifier
Metastasis
Online-Zugang:https://doi.org/10.1186/s40364-025-00885-w
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