TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

ABSTRACT Pathological cardiac hypertrophy is a major predisposing factor for heart failure (HF). This study investigates the role of the E3 ubiquitin ligase Tripartite Motif‐Containing 40 (TRIM40) in cardiac hypertrophy. Using TRIM40 knockout (TRIM40−/−), cardiac‐specific knockdown and overexpressin...

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Prif Awduron:	Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2026-03-01
Cyfres:	Advanced Science
Pynciau:	angiotensin II cardiac hypertrophy heart failure PKN2 transverse aortic constriction TRIM40
Mynediad Ar-lein:	https://doi.org/10.1002/advs.202521337
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!