Biology and evolving management of resectable dMMR/MSI-H cancers: current status and future perspectives

Abstract Mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) tumors represent a biologically and immunologically distinct subset of solid malignancies. Defective DNA mismatch repair mechanisms in these tumors lead to the accumulation of insertion-deletion mutations, a hypermu...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Tokiyoshi Tanegashima, Masaki Shiota, Kayo Toyosaki, Kouta Funakoshi, Masatoshi Eto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-11-01
coleção:	Cancer Immunology, Immunotherapy
Assuntos:	dMMR MSI-H Neoadjuvant immunotherapy Immune checkpoint inhibitor Non-operative Organ preservation
Acesso em linha:	https://doi.org/10.1007/s00262-025-04223-9
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!