Sex-informed estrogen receptor modulation in schizophrenia: a male-focused ERβ/GPER1 framework for cognitive and negative symptoms
Treatment-resistant schizophrenia (TRS) remains a major unmet clinical need, particularly in males who exhibit more severe negative and cognitive symptoms and limited responsiveness to dopamine-based therapies. Estrogenic signaling—especially through estrogen receptor beta (ERβ) and the G-protein–co...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2026-02-01
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| coleção: | Frontiers in Psychiatry |
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| Acesso em linha: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1714569/full |
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