Examining the Impact of Storage Conditions on the Stability of a Liquid Formulation of mRNA-Loaded Lipid Nanoparticles

<b>Background/Objectives</b>: This study investigated the effect of storage conditions on mRNA-LNPs in situ via identification of the formulation traits necessary for improving storage stability. <b>Methods</b>: We synthesized an ionizable lipid, namely TOT-28, which has a hydrolysis-susceptible est...

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Библиографические подробности

Главные авторы:	Mina Sato, Eleni Samaridou, Moritz Beck-Broichsitter, Masatoshi Maeki, Shunsuke Kita, Manabu Tokeshi, Katsumi Maenaka, Hideyoshi Harashima, Yusuke Sato
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2025-09-01
Серии:	Pharmaceutics
Предметы:	lipid nanoparticles mRNA delivery storage stability pH temperature
Online-ссылка:	https://www.mdpi.com/1999-4923/17/9/1194
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