Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila

Down syndrome (DS) is characterised by abnormal cognitive and motor development, and later in life by progressive Alzheimer's disease (AD)-like dementia, neuropathology, declining motor function and shorter life expectancy. It is caused by trisomy of chromosome 21 (Hsa21), but how individual Hsa21 g...

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Autors principals:	Simon A. Lowe, Maria M. Usowicz, James J.L. Hodge
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2019-05-01
Col·lecció:	Neurobiology of Disease
Matèries:	Down's syndrome Alzheimer's disease DYRK1A/minibrain Drosophila Neuromuscular junction Synaptic transmission
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996118303334
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