Single-cell derived tumor organoids display diversity in HLA class I peptide presentation
Immunotherapy may exploit alternative vulnerabilities of drug resistant cells. Here, the authors show that the HLA peptide presentation landscape is heterogeneous even within one individual, hinting that a multi-peptide vaccination approach against highly conserved tumor suppressors may be needed.
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| Principais autores: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2020-10-01
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| Colecção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-020-19142-9 |
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