Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund’s adjuvant, cyclophosphamide, and polyICLC (Mel63)

Background Peptide vaccines designed to stimulate melanoma-reactive CD4+ T cells can induce T cell and antibody (Ab) responses, associated with enhanced overall survival. We hypothesized that adding toll-like receptor 3 agonist polyICLC to an incomplete Freund’s adjuvant (IFA) would be safe and woul...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kelly T Smith, Nikole Varhegyi, Nolan A Wages, Emily H Hall, Kathleen Haden, Craig L Slingluff, Jr., Lynn T Dengel, Anna Dickinson, Caroline Reed, Elizabeth M Gaughan, Varinder Kaur, Nadejda V Galeassi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMJ Publishing Group 2021-01-01
Schriftenreihe:	Journal for ImmunoTherapy of Cancer
Online-Zugang:	https://jitc.bmj.com/content/9/1/e000934.full
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