Duchenne Muscular Dystrophy Patient iPSCs—Derived Skeletal Muscle Organoids Exhibit a Developmental Delay in Myogenic Progenitor Maturation

Background: Duchenne muscular dystrophy (DMD), which affects 1 in 3500 to 5000 newborn boys worldwide, is characterized by progressive skeletal muscle weakness and degeneration. The reduced muscle regeneration capacity presented by patients is associated with increased fibrosis. Satellite cells (SCs...

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Detalhes bibliográficos

Principais autores:	Urs Kindler, Lampros Mavrommatis, Franziska Käppler, Dalya Gebrehiwet Hiluf, Stefanie Heilmann-Heimbach, Katrin Marcus, Thomas Günther Pomorski, Matthias Vorgerd, Beate Brand-Saberi, Holm Zaehres
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-07-01
coleção:	Cells
Assuntos:	skeletal muscle organoids myogenesis myogenic progenitors satellite cells FAPs
Acesso em linha:	https://www.mdpi.com/2073-4409/14/13/1033
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