Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy

Abstract Diffuse midline glioma H3K27M-altered (DMG) remains a fatal pediatric brain cancer driven by a global loss of histone H3K27 trimethylation. Radiotherapy comprises the most important treatment modality and significantly improves overall survival. Novel therapeutic strategies for DMG patients...

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Principais autores:	Nikita Gorainow, Felix Sander, Daniel Picard, Marvin Christopher Frölich, Katharina Eul, Sarah Etemadi Afshar, Julia Asche, Michelle Monje, Eric Raabe, Jasmin Bartl, Arndt Borkhardt, Guido Reifenberger, Nicole Dünker, Maike Busch, David Pauck, Nan Qin, Johann Matschke, Marc Remke, Verena Jendrossek
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2026-03-01
Series:	Cell Death and Disease
Acceso en liña:	https://doi.org/10.1038/s41419-026-08567-7
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