Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

Abstract Lichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes, marked by T cell infiltration and keratinocyte apoptosis. However, its immune microenvironment remains poorly understood. Using single-cell RNA sequencing, spatial transcriptomics, and proteomics on sampl...

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Autores principales:	Rundong Jiang, Rachael Bogle, Xianying Xing, Joseph Kirma, Jennifer Fox, Paul W. Harms, Tran Do, Allison C. Billi, J. Michelle Kahlenberg, Robert L. Modlin, Rosane Teles, Julie West, Aaron Mangold, Haihan Zhang, Martin A. Schneider, Sandro Bruno, Ben Roediger, Georg Martiny-Baron, Lam C. Tsoi, Feriel Hacini-Rachinel, Till A. Röhn, Johann E. Gudjonsson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-03-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-70506-z
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