Development of a cyst-targeted therapy for polycystic kidney disease using an antagonistic dimeric IgA monoclonal antibody against cMET

Summary: Polycystic kidney disease (PKD) is characterized by the development of fluid-filled kidney cysts and relentless progression to renal failure. Current treatments have adverse effects and limited efficacy, enhancing the need for improved therapeutics. Here, we provide a proof of concept for t...

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Detalhes bibliográficos

Principais autores:	Margaret F. Schimmel, Bryan C. Bourgeois, Alison K. Spindt, Sage A. Patel, Tiffany Chin, Gavin E. Cornick, Yuqi Liu, Thomas Weimbs
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Cell Reports Medicine
Assuntos:	dimeric IgA pIgR PKD cMET monoclonal antibody therapy drug delivery
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666379125004082
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