APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

Summary: Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. Mutations in the tumor-suppressor APC initiate CRC in part by preventing the glycogen synthase kinase 3 (GSK3) kinase from phosphorylating β-CATENIN, leading to its stabilization and transactivation of mitogenic t...

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Autors principals:	Zvi Cramer, Keara Monaghan, Ricardo Petroni, Xin Wang, Stephanie Adams-Tzivelekidis, Kayla Durning, Melissa S. Kim, Yuhua Tian, Nicolette M. Johnson, María F. Carrera Rodríguez, Xiaoyuan Gao, Nicolae A. Leu, Simone Sidoli, Ning O. Li, M. Andres Blanco, Christopher J. Lengner
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-03-01
Col·lecció:	Cell Reports
Matèries:	CP: cancer CP: molecular biology
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124726001233
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