Modelling cholinergic and dopaminergic function over time in Parkinson’s disease with and without GBA1 variants

Abstract Parkinson’s Disease (PD) patients carrying GBA1-variants (GBA-PD) often show a faster cognitive decline, suggesting accelerated cholinergic degeneration. This study investigated changes over time in whole-brain cholinergic innervation within the context of dopaminergic changes and clinical...

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Detaylı Bibliyografya
Asıl Yazarlar:	Sofie Slingerland, Eline K. R. de Meyer, Harm J. van der Horn, Giulia Carli, Anne C. Slomp, Emile d’Angremont, Jeffrey M. Boertien, Ingeborg Goethals, Sanne K. Meles, Sygrid van der Zee, Teus van Laar
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Nature Portfolio 2025-11-01
Seri Bilgileri:	npj Parkinson's Disease
Online Erişim:	https://doi.org/10.1038/s41531-025-01160-3
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Modelling cholinergic and dopaminergic function over time in Parkinson’s disease with and without GBA1 variants

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