Deriving toxicity thresholds for hexabromocyclododecanes by cross-species and cross-route extrapolations on the basis of a human multiroute physiologically based toxicokinetic model

Hexabromocyclododecane (HBCD), a prevalent brominated flame retardant, consists predominantly of three isomers: α-HBCD, β-HBCD, and γ-HBCD. The paucity of health-based guidance values (HBGVs) currently hinders the evaluation of human health risks associated with HBCD exposure. The aim of this study...

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Autores principales:	Tianqing Guo, Hongbin Cao, Siqi Liu, Yilin Tang, Sun Yue, Ruidi Zhang, Tong Lyu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-03-01
Colección:	Ecotoxicology and Environmental Safety
Materias:	PBTK Modeling HBCD Cross-species extrapolation Route-to-route extrapolation Toxicity parameters
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0147651326003155
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