CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis

Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and bone destruction. Abnormal TNF/TNFR signaling leads to various dysregulations in Fibroblast-like synoviocytes (FLSs), including proliferation, migration, and cytokine production. CKLF like...

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Detalhes bibliográficos

Principais autores:	Xiaomeng Luo, Lingling Xu, Juan Cai, Siyang Ma, Haining Song, Pingting Yang, Chunshu Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
Colecção:	Journal of Orthopaedic Translation
Assuntos:	CMTM6 TAK1 Fibroblast-like synoviocytes Rheumatoid arthritis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2214031X25001603
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