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Interpretable deep generative ensemble learning for single-cell omics with Hydra

Abstract Single-cell omics enable the dissection of cellular heterogeneity, yet the high dimensionality, inherent noise, and sparsity present significant challenges. These challenges are amplified for rare cell populations, which are often difficult to annotate reliably but can be central to develop...

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Autors principals: Manoj M Wagle, Chunlei Liu, Zunpeng Liu, Yongheng Wang, Manolis Kellis, Ellis Patrick, Pengyi Yang
Format: Artigo
Idioma:Inglês
Publicat: Springer Nature 2026-04-01
Col·lecció:Molecular Systems Biology
Accés en línia:https://doi.org/10.1038/s44320-026-00208-7
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