Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques

ABSTRACT Alternative delivery routes of the current Mycobacterium tuberculosis (Mtb) vaccine, intradermally (ID) delivered BCG, may provide better protection against tuberculosis, and be more easily administered. Here, we use rhesus macaques to compare the airway immunogenicity of BCG delivered via...

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Hauptverfasser:	Stella G. Hoft, Keith D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Daniel F. Hoft, Richard Herbert, Daniel L. Barber
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2023-04-01
Schriftenreihe:	mBio
Schlagworte:	BCG CD4 T cells immunization immunology lung defense rhesus macaques
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.00220-23
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